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Copper-Catalyzed Trifluoromethylation of Polysubstituted Alkenes Assisted by Decarboxylation

Zhengbiao He, Ping Tan and Jinbo Hu*

*Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China, Email:

Z. He, P. Tan, J. Hu, Org. Lett., 2016, 18, 72-75.

DOI: 10.1021/acs.orglett.5b03290 (free Supporting Information)

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An efficient copper-catalyzed trifluoromethylation of polysubstituted alkenes assisted by decarboxylation of β,γ-unsaturated carboxylic acids provides allylic and vinylic CF3-substituted compounds under mild conditions.

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Key Words


ID: J54-Y2016