Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of 1,2-Dicarbonyl Compounds
Xiaoyu Ren and Haifeng Du*
*Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email: haifengduiccas.ac.cn
X. Ren, H. Du, J. Am. Chem. Soc., 2016, 138, 810-813.
DOI: 10.1021/jacs.5b13104 (free Supporting Information)
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A combination of tricyclohexylphosphine and chiral alkenylborane derived in situ from a diyne as a frustrated Lewis pair catalyst enables a highly enantioselective hydrosilylation of 1,2-dicarbonyl compounds. Various optically active α-hydroxy ketones and esters were obtained in good yields with high ee's.
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