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Transition Metal-Free Visible Light-Driven Photoredox Oxidative Annulation of Arylamidines

Zi-chao Shen, Pan Yang and Yu Tang*

*School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University, Tianjin, 300072 P. R. China, Email: yutangtju.edu.cn

Z.-c. Shen, P. Yang, Y. Tang, J. Org. Chem., 2016, 81, 309-317.

DOI: 10.1021/acs.joc.5b02366 (free Supporting Information)


Abstract

A metal-free visible light-mediated oxidative coupling catalyzed by a photoredox organocatalyst enables a fast synthesis of multisubstituted quinazolines from readily available amidines. The protocol features low catalyst loading.

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Key Words

quinazolines


ID: J42-Y2016