Ruthenium-Catalyzed Urea Synthesis Using Methanol as the C1 Source
Seung Hyo Kim and Soon Hyeok Hong*
*Department of Chemistry, College of Natural Sciences, Seoul
National University, Seoul 151-747, Republic of Korea, Email: soonhong
snu.ac.kr
S. H. Kim, S. H. Hong, Org. Lett., 2016, 18, 212-215.
DOI: 10.1021/acs.orglett.5b03328
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Abstract
Commercially available ruthenium pincer complexes as catalysts enable an urea synthesis directly from methanol and amine without additive, such as a base, oxidant, or hydrogen acceptor. The reaction is highly atom-economical, producing hydrogen as the sole byproduct. Furthermore, unsymmetrical urea derivatives were successfully obtained via a one-pot, two-step reaction.
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Key Words
ID: J54-Y2016
