Cobalt-Catalyzed N-Alkylation of Amines with Alcohols
Guoqi Zhang*, Zhiwei Yin and Shengping Zheng
*Department of Sciences, John Jay College & The Graduate Center, The City University of New York, 10019 New York, NY, Email: guzhangjjay.cuny.edu
G. Zhang, Z. Yin, S. Zheng, Org. Lett., 2016, 18, 300-303.
DOI: 10.1021/acs.orglett.5b03461 (free Supporting Information)
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The addition of 4 Å molecular sieves enables an efficient cobalt(II)-catalyzed N-alkylation of both aromatic and aliphatic amines with alcohols with high chemoselectivity (amines vs imines). A hydrogen-borrowing mechanism is responsible for the tandem acceptorless dehydrogenation/condensation/hydrogenation process.
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