Phosphorous Acid Promoted Hydration-Condensation of Aromatic Alkynes with Aldehydes Affording Chalcones in an Oil/Water Two-Phase System
Yongbo Zhou*, Zhongwen Li, Xiao Yang, Xiulin Chen, Mei Li, Tieqiao Chen, Shuang-Feng Yin*
*State Key Laboratory of Chemo/Biosensing and Chemometrics,
College of Chemistry and Chemical Engineering, Hunan University, Changsha
410082, P. R. of China, Email: sf_yin
hnu.edu.cn
Y. Zhou, Z. Li, X. Yang, X. Chen, M. Li, T. Chen, S.-F. Yin, Synthesis, 2016, 48, 231-237.
Abstract
A phosphorous acid promoted alkyne-aldehyde hydration-condensation enables a simple and environmentally benign synthesis of chalcones in high to excellent yields in an oil/water two-phase system.
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Key Words
phosphorous acids, two-phase systems, chalcones, hydration, condensation, green chemistry
ID: J66-Y2016
