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Microwave-Assisted Nickel-Catalyzed One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles

Tejpal Singh Chundawat, Nutan Sharma, Poonam Kumari, Sunita Bhagat*

*Organic Synthesis Research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi, New Delhi-110021, India, Email:

T. S. Chundawat, N. Sharma, P. Kumari, S. Bhagat, Synlett, 2016, 27, 404-408.

DOI: 10.1055/s-0035-1560825


A Schiff's base complex nickel catalyst (Ni-C) enables a highly efficient one-pot microwave-assisted synthesis of 2,4,5-trisubstituted imidazoles in excellent yields from aldehydes, benzil, and ammonium acetate. The catalyst could be easily recovered by simple filtration and reused.

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Key Words

multicomponent reactions, catalysis, imidazoles, microwave synthesis, cyclization

ID: J60-Y2016