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A Palladium-Catalyzed Three-Component Synthesis of Arylmethylsulfonamides

Tamara Beisel, Georg Manolikakes*

*Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany, Email:

T. Beisel, G. Manolikakes, Synthesis, 2016, 48, 379-386.

DOI: 10.1055/s-0035-1560910 (free Supporting Information)


A palladium-catalyzed three-component synthesis of arylmethylsulfonamide derivatives from sulfonamides, paraformaldehyde, and arylboronic acids is operationally simple and provides a broad range of structurally interesting sulfonamidomethyl compounds.

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Key Words

multicomponent reactions, palladium, sulfonamides (sulfonamidation, arylation), Petasis reaction, paraformaldehyde, arylboronic acids

ID: J66-Y2016