Organic Chemistry Portal



Palladium-Catalyzed Alkylarylation of Acrylamides with Unactivated Alkyl Halides

Hua Wang, Li-Na Guo and Xin-Hua Duan*

*Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China, Email:

H. Wang, L.-N. Guo, X.-H. Duan, J. Org. Chem., 2016, 81, 860-867.

DOI: 10.1021/acs.joc.5b02433

see article for more reactions


An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides offers broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A radical pathway is probably involved in the cyclization process.

see article for more examples

Key Words


ID: J42-Y2016