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Organoselenium-Catalyzed Synthesis of Oxygen- and Nitrogen-Containing Heterocycles

Ruizhi Guo, Jiachen Huang, Haiyan Huang and Xiaodan Zhao*

*Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China, Email:

R. Guo, J. Huang, H. Huang, X. Zhao, Org. Lett., 2016, 18, 504-507.

DOI: 10.1021/acs.orglett.5b03543

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Organoselenium catalysis enables an efficient synthesis of oxygen and nitrogen heterocycles via exo-cyclization under mild conditions in the presence of 1-fluoropyridinium triflate. The reaction offers good functional group tolerance and excellent regioselectivity.

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Key Words

tetrahydrofurans, pyrrolidines, N-fluoropyridinium triflate

ID: J54-Y2016