Organic Chemistry Portal



1,1′-Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization To Generate [1,2,4]Triazolo[4,3-a]pyridines

Kyle D. Baucom, Siān C. Jones and Scott W. Roberts*

*Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 31320, United States, Email:

K. D. Baucom, S. C. Jones, S. W. Roberts, Org. Lett., 2016, 18, 560-563.

DOI: 10.1021/acs.orglett.5b03589

see article for more reactions


An operationally efficient CDI mediated tandem coupling and cyclization reaction provides [1,2,4]triazolo[4,3-a]pyridines. The methodology is suitable for batch mode as well as continuous process.

see article for more examples

Key Words


ID: J54-Y2016