1,1′-Carbonyldiimidazole (CDI) Mediated Coupling and Cyclization To Generate [1,2,4]Triazolo[4,3-a]pyridines
Kyle D. Baucom, Siān C. Jones and Scott W. Roberts*
*Drug Substance Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 31320, United States, Email: scottr01amgen.com
K. D. Baucom, S. C. Jones, S. W. Roberts, Org. Lett., 2016, 18, 560-563.
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An operationally efficient CDI mediated tandem coupling and cyclization reaction provides [1,2,4]triazolo[4,3-a]pyridines. The methodology is suitable for batch mode as well as continuous process.
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