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An Eco-friendly, Hantzsch-Based, Solvent-Free Approach to 2-Aminothiazoles and 2-Aminoselenazoles

Victor Facchinetti, Marcela M. Avellar, Ana C. S. Nery, Claudia R. B. Gomes, Thatyana R. A. Vasconcelos, Marcus V. N. de Souza*

*Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos - Farmanguinhos, Rua Sizenando Nabuco 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil, Email: marcos_souzafar.fiocruz.br

V. Facchinetti, M. M. Avellar, A. C. S. Nery, C. R. B. Gomes, T. R. A. Vasconcelos, M. V. N. de Souza, Synthesis, 2016, 48, 437-440.

DOI: 10.1055/s-0035-1560534 (free Supporting Information)


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Abstract

Hantzsch condensation of 2-bromoacetophenones with thiourea or selenourea enables a simple, fast, and eco-friendly solvent-free synthesis of 2-aminothiazoles and 2-amino-1,3-selenazoles without the use of a catalyst. Reactions proceed to completion in a few seconds and products are obtained in good yields after easy workup.

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Key Words

thiazoles, 1,3-selenazoles, synthesis, solvent-free, heterocycles


ID: J66-Y2016