Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage
Zisong Qi, Songjie Yu and Xingwei Li*
*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China, Email: xwlidicp.ac.cn
Z. Qi, S. Yu, X. Li, Org. Lett., 2016, 18, 700-703.
DOI: 10.1021/acs.orglett.5b03669 (free Supporting Information)
A Rh(III)-catalyzed C-H activation/annulation of imidamides with α-diazo β-ketoesters enables the synthesis of N-unprotected indoles. A rhodacyclic intermediate has been isolated and a plausible mechanism has been proposed.
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