Palladium-Catalyzed C-H Functionalization of Aromatic Oximes: A Strategy for the Synthesis of Isoquinolines
Zhongzhi Zhu, Xiaodong Tang, Xianwei Li, Wanqing Wu, Guohua Deng* and Huanfeng Jiang*
*School of Chemistry and Chemical Engineering, South China
University of Technology, Guangzhou 510640, People's Republic of China, Email:
ghdeng
scut.edu.cn, jianghfscut.edu.cn
Z. Zhu, X. Tang, X. Li, W. Wu, G. Deng, H. Jiang, J. Org. Chem., 2016, 81, 1401-1409.
DOI: 10.1021/acs.joc.5b02376
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Abstract
Oximes serve as a directing group and an internal oxidant in an efficient strategy for synthesis of isoquinolines via Pd(II)-catalyzed homocoupling or cyclization with vinyl azides. This reaction features good functional group tolerance and provides various isoquinolines under mild conditions.
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Key Words
ID: J42-Y2016
