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Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

Thomas D. Montgomery and Viresh H. Rawal*

*Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States, Email: vrawaluchicago.edu

T. D. Montgomery, V. H. Rawal, Org. Lett., 2016, 18, 740-743.

DOI: 10.1021/acs.orglett.5b03708 (free Supporting Information)


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Abstract

A palladium-catalyzed cyclization reaction for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles couples two of the carbons of a propargyl unit with various diamine components to provide products in very good yields with high regio- and stereochemical control.


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Key Words

Piperazines, N-Heterocycles


ID: J54-Y2016