Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
Thomas D. Montgomery and Viresh H. Rawal*
*Department of Chemistry, University of Chicago, Chicago,
Illinois 60637, United States, Email: vrawal
uchicago.edu
T. D. Montgomery, V. H. Rawal, Org. Lett., 2016, 18, 740-743.
DOI: 10.1021/acs.orglett.5b03708
see article for more reactions
Abstract
A palladium-catalyzed cyclization reaction for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles couples two of the carbons of a propargyl unit with various diamine components to provide products in very good yields with high regio- and stereochemical control.
see article for more examples
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Key Words
ID: J54-Y2016
