Aryl Nitriles from Alkynes Using tert-Butyl Nitrite: Metal-Free Approach to C≡C Bond Cleavage

Uttam Dutta, David W. Lupton* and Debabrata Maiti*

*IITB-Monash Research Academy, IIT Bombay, Powai, Mumbai-400076, India, Email: dmaitichem.iitb.ac.in, david.luptonmonash.edu

U. Dutta, D. W. Lupton, D. Maiti, Org. Lett., 2016, 18, 860-863.

DOI: 10.1021/acs.orglett.6b00147

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Abstract

A metal-free C≡C bond cleavage of terminal alkynes in the presence of tBuONO as a powerful nitrogenating agent provides a vast range of nitriles containing aryl, heteroaryl, and natural product derivatives.

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Key Words

Nitriles, tert-Butyl Nitrite, N-Oxides

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ID: J54-Y2016