Visible-Light-Mediated Synthesis of Amides from Aldehydes and Amines via in Situ Acid Chloride Formation
Naeem Iqbal and Eun Jin Cho*
*Department of Chemistry and Applied Chemistry, Hanyang
University, Ansan 426-791, Republic of Korea, Email: ejcho
cau.ac.kr
N. Iqbal, E. J. Cho, J. Org. Chem., 2016, 81, 1905-1911.
Abstract
Using an efficient visible-light photocatalysis-based method, a mixture of an aldehyde, tert-butyl hydrogen peroxide, and N-chlorosuccinimide afforded an acid chloride in the presence of Ru(bpy)3Cl2 as photocatalyst. A subsequent reaction with an amine provided the corresponding amide.
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Key Words
oxidative amidation, TBHP, NCS, acyl chlorides
ID: J42-Y2016
