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Simple and Mild Synthesis of Indoles via Hydroamination Reaction Catalysed by NHC-Gold Complexes: Looking for Optimized Conditions

Malina Michalska*, Karol Grela*

*Faculty of Chemistry, University of Warsaw, Zwirki I Wigury 101, 02-089 Warsaw; Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Email: mmichalskacnbc.uw.edu.pl, karol.grelagmail.com

M. Michalska, K. Grela, Synlett, 2016, 27, 599-603.

DOI: 10.1055/s-0035-1560976 (free Supporting Information)


Abstract

An efficient heterocyclization of 2-alkynylanilines provides indoles in very good yields under mild conditions using small amounts of a gold precatalyst. Various functional groups are tolerated.


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Key Words

gold, hydroamination, heterocyclization, 2-alkynylanilines, indoles


ID: J60-Y2016