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Nickel-Catalyzed Hydroacylation of Styrenes with Simple Aldehydes: Reaction Development and Mechanistic Insights

Li-Jun Xiao, Xiao-Ning Fu, Min-Jie Zhou, Jian-Hua Xie, Li-Xin Wang, Xiu-Fang Xu* and Qi-Lin Zhou*

*Department of Chemistry, Nankai University, Tianjin 300071, China, Email:,

L.-J. Xiao, X.-N. Fu, M.-J. Zhou, J.-H. Xie, L.-X. Wang, X.-F. Xu, Q.-L. Zhou, J. Am. Chem. Soc., 2016, 138, 2957-2960.

DOI: 10.1021/jacs.6b00024

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A nickel-catalyzed intermolecular hydroacylation reaction of alkenes with simple aldehydes offers an approach to the selective preparation of branched ketones in high yields and selectivities. The origin of the reactivity and regioselectivity of this reaction was investigated computationally.

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ID: J48-Y2016