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Regiospecific Synthesis of Benzoxepines through Pd-Catalyzed Carbene Migratory Insertion and C-C Bond Cleavage

Yang Xie, Ping Zhang and Lei Zhou*

*School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China, Email: zhoul39mail.sysu.edu.cn

Y. Xie, P. Zhang, L. Zhou, J. Org. Chem., 2016, 81, 2128-2134.

DOI: 10.1021/acs.joc.5b02413 (free Supporting Information)


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Abstract

Various benzoxepines were constructed by a regioselective ring expansion concomitant with the introduction of an aryl group at position 5 via migratory insertion into a Pd carbene followed by C-C bond cleavage.

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Key Words

Benzoxepines


ID: J42-Y2016