Phosphorothiolation of Aryl Boronic Acids Using P(O)H Compounds and Elemental Sulfur
Jian Xu, Liangliang Zhang, Xueqin Li, Yuzhen Gao, Guo Tang* and Yufen Zhao
*Department of Chemistry, College of Chemistry and Chemical
Engineering, and the Key Laboratory for Chemical Biology of Fujian Province,
Xiamen University, Xiamen, Fujian 361005, China, Email: t12g21
xmu.edu.cn
J. Xu, L. Zhang, X. Li, Y. Gao, G. Tang, Y. Zhao, Org. Lett., 2016, 18, 1100-1103.
DOI: 10.1021/acs.orglett.6b00118
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Abstract
A multicomponent reaction involving aryl boronic acids, elemental sulfur, and P(O)H compounds provides valuable S-aryl phosphorothioates and S-aryl phosphorodithioates in excellent yields. Moreover, this method can be easily scaled up.
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L. Zhang, P. Zhang, X. Li, J. Xu, G. Tang, Y. Zhao, J. Org. Chem., 2016, 81, 5566-5573.
Key Words
phosphorothioates, phosphorothiolation, multicomponent reactions
ID: J54-Y2016
