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Benzylic Phosphates in Friedel-Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes

Gangaram Pallikonda and Manab Chakravarty*

*Department of Chemistry, Birla Institute of Technology and Sciences, Pilani Hyderabad Campus, Jawahar nagar, Shameerpet Mandal, Hyderabad, Telangana 500078, India, Email:

G. Pallikonda, M. Chakravarty, J. Org. Chem., 2016, 81, 2135-2142.

DOI: 10.1021/acs.joc.5b02441 (free Supporting Information)

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Easily reachable electron-poor/rich primary and secondary benzylic phosphates are suitably substrates for Friedel-Crafts benzylation reactions with only 1.2 equiv activated/deactivated arenes without additional solvent to access structurally and electronically diverse triarylmethanes, diarylethanes, and diarylmethanes with excellent yields and selectivities at room temperature within short reaction times.

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Key Words

Friedel-Crafts Alkylation, benzylation

ID: J42-Y2016