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Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

Fen Wang, He Wang, Qiang Wang, Songjie Yu and Xingwei Li*

*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, Email:

F. Wang, H. Wang, Q. Wang, S. Yu, X. Li, Org. Lett., 2016, 18, 1306-1309.

DOI: 10.1021/acs.orglett.6b00227 (free Supporting Information)

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C-H activation of arenes enables the synthesis of heterocycles via annulations between arenes and unsaturated coupling partners. Whereas nitriles fail to act as coupling partners, dioxazolones can be employed as synthons of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provides two classes of quinazolines under Co(III)-catalysis.

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Key Words


ID: J54-Y2016