Organic Chemistry Portal



Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones

Youzhi Wu, Peng Sun, Kaifan Zhang, Tie Yang, Hequan Yao* and Aijun Lin*

*State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China, Email:,

Y. Wu, P. Sun, K. Zhang, T. Yang, H. Yao, A. Lin, J. Org. Chem., 2016, 81, 2166-2173.

DOI: 10.1021/acs.joc.5b02824 (free Supporting Information)

see article for more reactions


A Rh-catalyzed redox-neutral annulation of primary benzamides with diazo compounds provides isoquinolinones. This efficient and economic procedure exhibited good functional group tolerability, scalability, and regioselectivity, obviating the need for oxidants, and only environmentally benign N2 and H2O were released.

see article for more examples

Key Words


ID: J42-Y2016