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Hydrazine in the Ugi Tetrazole Reaction

Pravin Patil, Ji Zhang, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling*

*University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands, Email:

P. Patil, J. Zhang, K. Kurpiewska, J. Kalinowska-Tłuścik, A. Dömling, Synthesis, 2016, 48, 1122-1130.

DOI: 10.1055/s-0035-1561353

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The use of N-Boc-protected hydrazine in the Ugi tetrazole reaction provides a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles in good yield.

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Key Words

hydrazines, isocyanides, tetrazoles, multicomponent reactions

ID: J66-Y2016