Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes
Jianhui Chen, Chenhui Chen, Chonglei Ji and Zhan Lu*
*Department of Chemistry, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China, Email: luzhanzju.edu.cn
J. Chen, C. Chen, C. Ji, Z. Lu, Org. Lett., 2016, 18, 1594-1597.
DOI: 10.1021/acs.orglett.6b00453 (free Supporting Information)
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In a highly enantioselective cobalt-catalyzed hydrogenation of 1,1-diarylethenes at ambient conditions with a bench-stable chiral oxazoline iminopyridine-cobalt complex as precatalyst, a unique o-chloride effect achieves high enantioselectivity. Easy removal as well as further transformations of the chloro group make this protocol a potentially useful alternative to synthesize various chiral 1,1-diarylethanes.
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