Catalytic Difluorination of Olefins

István Gábor Molnár and Ryan Gilmour*

*Institute for Organic Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany, Email: ryan.gilmouruni-muenster.de

I. G. Molnár, R. Gilmour, J. Am. Chem. Soc., 2016, 138, 5004-5007.

DOI: 10.1021/jacs.6b01183

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Abstract

A catalytic, vicinal difluorination of olefins displays broad functional group tolerance, using inexpensive p-iodotoluene as the catalyst. Preliminary efforts toward the development of an enantioselective variant are reported.

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tentative mechanistic proposal

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Key Words

1,2-difluoroalkanes, selectfluor, hypervalent iodine compounds, organocatalysis

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ID: J48-Y2016