Organic Chemistry Portal



An Efficient Biomimetic Aerobic Oxidation of Alcohols Catalyzed by Iron Combined with Amino Acids

Guofu Zhang, Shasha Li, Jie Lei, Guihua Zhang, Xiaoqiang Xie, Chengrong Ding*, Renhua Liu*

*Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014; East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China, Email:,

G. Zhang, S. Li, J. Lei, G. Zhang, X. Xie, C. Ding, R. Liu, Synlett, 2016, 27, 956-960.

DOI: 10.1055/s-0035-1561290

see article for more reactions


A combination of FeCl3, L-valine and TEMPO oxidizes a wide range of primary/secondary benzyl, allylic, and heterocyclic alcohols to aldehydes and ketones with good to excellent isolated yields in the presence of oxygen.

see article for more examples

Key Words

alcohols, aldehydes, amino acids, iron, ketones, oxidation, TEMPO, oxygen

ID: J60-Y2016