An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides
Seiya Katahara, Shoichiro Kobayashi, Kanami Fujita, Tsutomu Matsumoto, Takaaki Sato* and Noritaka Chida*
*Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan, Email: takaakisapplc.keio.ac.jp, chidaapplc.keio.ac.jp
S. Katahara, S. Kobayashi, K. Fujita, T. Matsumoto, T. Sato, N. Chida, J. Am. Chem. Soc., 2016, 138, 5246-5249.
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An Ir-catalyzed reductive formation of functionalized nitrones from N-hydroxyamides via dehydrosilylation and hydrosilylation showed high chemoselectivity in the presence of sensitive functional groups, such as methyl esters. The reaction was successfully applied to the synthesis of cyclic and macrocyclic nitrones, which are known to be challenging compounds.
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