Exploiting the Bis-Nucleophilicity of α-Aminoboronates: Copper-Catalyzed, Intramolecular Aminoalkylations of Bromobenzoyl Chlorides
Aaron M. Dumas*, Adrian J. Sieradzki and Liam J. Donnelly
*Department of Process Chemistry, Merck Sharp and Dohme Ltd.,
Hertford Road, Hoddesdon EN11 9BU, United Kingdom, Email: aaron.michael.dumas
gmail.com
A. M. Dumas, A. J. Sieradzki, L. J. Donnelly, Org. Lett., 2016, 18, 1848-1851.
DOI: 10.1021/acs.orglett.6b00586
Abstract
An acylation/arylation reaction of α-aminoboronate salts with 2-bromobenzoyl chlorides provides isoindolinones in very good yields under mild conditions via an intramolecular, Cu-catalyzed sp3-sp2 coupling.
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Key Words
ID: J54-Y2016
