A Novel Synthesis of Disubstituted Quinazoline Diones with Differential N-Substitution via a Copper-Catalysed Cross-Coupling of Acyl Ureas
Emma Durham, Dave Perkins*, James S. Scott, Jimmy Wang, Sam Watson
*AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield,
SK10 4TG, UK, Email: dave.perkins
astrazeneca.com
E. Durham, D. Perkins, J. S. Scott, J. Wang, S. Watson, Synlett, 2016, 27, 965-968.
DOI: 10.1055/s-0035-1561500
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Abstract
An efficient method for the synthesis of disubstituted quinazoline diones with differential N-substitution proceeds in high yields under mild conditions. The reaction tolerates a wide range of substitutions on the aromatic and dione rings.
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Key Words
acyl ureas, quinazoline diones, quinazolinediones, copper-catalysed, Ullmann reaction, intramolecular cyclisation
ID: J60-Y2016
