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Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1-Disubstituted Hydrazines

Tao Wang, Xiao Di, Chao Wang*, Li Zhou and Jian Sun*

*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 China, Email:,

T. Wang, X. Di, C. Wang, L. Zhou, J. Sun, Org. Lett., 2016, 18, 1900-1903.

DOI: 10.1021/acs.orglett.6b00675

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Lewis base promoted direct reductive hydrazination enables a straightforward and facile synthesis of 1,1-disubstituted hydrazines with very good yields. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively, various ketones and aldehydes reacted with phenylhdrazines.

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Key Words

hydrazines, trichlorosilane

ID: J54-Y2016