Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1-Disubstituted Hydrazines

Tao Wang, Xiao Di, Chao Wang*, Li Zhou and Jian Sun*

*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 China, Email: wangchaocib.ac.cn, sunjiancib.ac.cn

T. Wang, X. Di, C. Wang, L. Zhou, J. Sun, Org. Lett., 2016, 18, 1900-1903.

DOI: 10.1021/acs.orglett.6b00675

---

see article for more reactions

Abstract

Lewis base promoted direct reductive hydrazination enables a straightforward and facile synthesis of 1,1-disubstituted hydrazines with very good yields. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively, various ketones and aldehydes reacted with phenylhdrazines.

see article for more examples

---

---

Key Words

hydrazines, trichlorosilane

---

ID: J54-Y2016