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Synthesis of Imidates: TFA-Mediated Regioselective Amide Alkylation Using Meerwein's Reagent

Kirill Popov and Peter Somfai*

*Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P.O. Box 124, 221 00 Lund, Sweden, Email:

K. Popov, P. Somfai, J. Org. Chem., 2016, 81, 3470-3472.

DOI: 10.1021/acs.joc.6b00424

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A simple and reliable protocol for regioselective O-alkylation of amides provides the corresponding imidates. Its scope and efficiency is demonstrated on a number of substrates.

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Key Words


ID: J42-Y2016