Organic Chemistry Portal



Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes

Santanu Hati, Subhabrata Sen*

*Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Chithera, Dadri, Gautam Buddha Nagar, Uttar Pradesh, 201314, India, Email:

S. Hati, S. Sen, Synthesis, 2016, 48, 1389-1398.

DOI: 10.1055/s-0035-1560416

see article for more reactions


A mild o-iodoxybenzoic acid (IBX) mediated tandem reaction of readily available o-aminobenzylamine and aldehydes enables a facile synthesis of diversely substituted quinazolines and 3,4-dihydroquinazolines in very good yields.

see article for more examples

Key Words

quinazolines, dihydroquinazolines, o-iodoxybenzoic acid, o-aminobenzylamine, aldehydes, IBX

ID: J66-Y2016