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Cp2TiCl2-Catalyzed Regioselective Hydrocarboxylation of Alkenes with CO2

Peng Shao, Sheng Wang, Chao Chen and Chanjuan Xi*

*Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: cjxitsinghua.edu.cn

P. Shao, S. Wang, C. Chen, C. Xi, Org. Lett., 2016, 18, 2050-2053.

DOI: 10.1021/acs.orglett.6b00665 (free Supporting Information)


Abstract

Cp2TiCl2-catalyzed exchange of alkenes with Grignard reagents and subsequent reaction with CO2 provides carboxylic acids in high yields. The reaction proceeds with a wide range of alkenes under mild conditions. Styrenes can be transformed to α-aryl carboxylic acids, and aliphatic alkenes give linear alkanoic acids.

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Key Words

hydrocarboxylation, α,β-unsaturated compounds


ID: J54-Y2016