Organic Chemistry Portal



Copper-Catalyzed Cascade Cycloamination of α-Csp3-H Bond of N-Aryl Ketimines with Azides: Access to Quinoxalines

Tengfei Chen, Xun Chen, Jun Wei, Dongen Lin*, Ying Xie and Wei Zeng*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China, Email:,

T. Chen, X. Chen, J. Wei, D. Lin, Y. Xie, W. Zeng, Org. Lett., 2016, 18, 2078-2081.

DOI: 10.1021/acs.orglett.6b00709

see article for more reactions


A copper-catalyzed cycloamination of α-Csp3-H bond of N-aryl ketimines with sodium azide provides an efficient access to quinoxalines. The reaction features mild conditions and a broad functional group tolerance.

see article for more examples

proposed mechanism

Key Words

Quinoxalines, PIDA

ID: J54-Y2016