Organic Chemistry Portal



Nickel-Catalyzed Phosphorylation of Phenol Derivatives via C-O/P-H Cross-Coupling

Jia Yang, Jing Xiao, Tieqiao Chen* and Li-Biao Han*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China; AIST, Tsukuba, Ibaraki 305-8565, Japan, Email:,

J. Yang, J. Xiao, T. Chen, L.-B. Han, J. Org. Chem., 2016, 81, 3911-3916.

DOI: 10.1021/acs.joc.6b00289 (free Supporting Information)

see article for more reactions


In an efficient nickel-catalyzed phosphorylation, various phenyl pivalates coupled readily with hydrogen phosphoryl compounds to afford the corresponding aryl phosphonates and aryl phosphine oxides in very good yields.

see article for more examples

plausible mechanism

Key Words


ID: J42-Y2016