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Silver-Catalyzed Decarboxylative Allylation of Aliphatic Carboxylic Acids in Aqueous Solution

Lei Cui, He Chen, Chao Liu and Chaozhong Li*

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email:

L. Cui, H. Chen, C. Liu, C. Li, Org. Lett., 2016, 18, 2188-2191.

DOI: 10.1021/acs.orglett.6b00802

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With K2S2O8 as the oxidant and AgNO3 as the catalyst, direct decarboxylative radical allylation of aliphatic carboxylic acids with allyl sulfones in aqueous CH3CN solution gave the corresponding alkenes in good yields under mild conditions. This site-specific allylation method exhibits wide functional group compatibility.

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Key Words

allylation, potassium peroxydisulfate

ID: J54-Y2016