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Manganese-Catalyzed Borylation of Unactivated Alkyl Chlorides

Thomas C. Atack and Silas P. Cook*

*Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, United States, Email:

T. C. Atack, S. P. Cook, J. Am. Chem. Soc., 2016, 138, 6139-6142.

DOI: 10.1021/jacs.6b03157


Very low amounts of Manganese(II) bromide and tetramethylethylenediamine (TMEDA) catalyze the cross coupling of (bis)pinacolatodiboron with a wide range of alkyl halides. This method allows access to primary, secondary, and tertiary boronic esters.

see article for more examples

Iron-Catalyzed Borylation of Alkyl Electrophiles

T. C. Atack, R. M. Lecker, S. P. Cook, J. Am. Chem. Soc., 2014, 136, 9521-9523.

Key Words


ID: J48-Y2016