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Indium(III) Chloride Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles from Oximes and Sodium Azide

Sravanthi Devi Guggilapu, Santosh Kumar Prajapti, Atulya Nagarsenkar, Keshav Kumar Gupta, Bathini Nagendra Babu*

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India, Email: bathini.niperhydgov.in

S. D. Guggilapu, S. K. Prajapti, A. Nagarsenkar, K. K. Gupta, B. N. Babu, Synlett, 2016, 27, 1241-1244.

DOI: 10.1055/s-0035-1561559



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Abstract

5-substituted 1H-tetrazole derivatives can be prepared in good to excellent yields from various oximes and sodium azide by using indium(III) chloride as a Lewis acid catalyst. The method has significant advantages, such as an inexpensive catalyst, low catalyst loading, mild reaction conditions, and a convenient experimental procedure.

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Key Words

tetrazoles, Lewis acids, catalysis, indium trichloride, sodium azide


ID: J60-Y2016