Silicon-Carbon Bond Formation via Nickel-Catalyzed Cross-Coupling of Silicon Nucleophiles with Unactivated Secondary and Tertiary Alkyl Electrophiles

Crystal K. Chu, Yufan Liang and Gregory C. Fu*

*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States, Email: gcfucaltech.edu

C. K. Chu, Y. Liang, G. C. Fu, J. Am. Chem. Soc., 2016, 138, 6404-6407.

DOI: 10.1021/jacs.6b03465

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Abstract

A simple, commercially available nickel catalyst (NiBr₂·diglyme) can achieve couplings of unactivated alkyl bromides with nucleophilic silicon reagents under unusually mild conditions.

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Key Words

alkylsilanes

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ID: J48-Y2016