Mild Metal-Free Hydrosilylation of Secondary Amides to Amines
Pei-Qiang Huang*, Qi-Wei Lang and Yan-Rong Wang
*Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, PR China, Email: pqhuangxmu.edu.cn
P.-Q. Huang, Q.-W. Lang, Y.-R. Wang, J. Org. Chem., 2016, 81, 4235-4243.
DOI: 10.1021/acs.joc.6b00572 (free Supporting Information)
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The combination of amide activation by Tf2O with B(C6F5)3-catalyzed hydrosilylation with TMDS enables a one-pot reduction of secondary amides to amines under mild conditions with broad applicability and excellent chemoselectivity for many sensitive functional groups.
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