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Practical Synthesis of Amides via Copper/ABNO-Catalyzed Aerobic Oxidative Coupling of Alcohols and Amines

Susan L. Zultanski, Jingyi Zhao and Shannon S. Stahl*

*Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States, Email:

S. L. Zultanski, J. Zhao, S. S. Stahl, J. Am. Chem. Soc., 2016, 138, 6416-6419.

DOI: 10.1021/jacs.6b03931

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A modular Cu/ABNO catalyst system enables efficient aerobic oxidative coupling of alcohols and amines to amides. All four permutations of benzylic/aliphatic alcohols and primary/secondary amines are viable in this reaction, enabling broad access to secondary and tertiary amides with excellent functional group compatibility within short reaction time at rt.

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Key Words

ABNO, amides, oxygen

ID: J48-Y2016