Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines
Yuan Huang, Rui-Zhi Huang and Yu Zhao*
*Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543, Email: zhaoyunus.edu.sg
Y. Huang, R.-Z. Huang, Y. Zhao, J. Am. Chem. Soc., 2016, 138, 6571-6576.
DOI: 10.1021/jacs.6b02372 (free Supporting Information)
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An effient cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines delivers a range of synthetically useful allylic alcohols and amines in high enantiopurity. This convenient method employs commercially available and easy to handle catalysts and reagents.
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