First Report on the Synthesis of Isatins via Pyridinium Chlorochromate Catalyzed Intramolecular Cyclization Reactions
Qiming Yue, Yaoling Wang, Li Hai, Li Guo, Hongmei Yin*, Yong Wu*
*Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. of China, Email: yinhongmeiscu.edu.cn, wyongscu.edu.cn
Q. Yue, Y. Wang, L. Hai, L. Guo, H. Yin, Y. Wu, Synlett, 2016, 27, 1292-1296.
Isatins can be synthesized from α-formyl amides in good yields via one-pot intramolecular cyclization-oxidation reaction in the presence of pyridinium chlorochromate (PCC). The reaction proceeded smoothly under air, offers a broad substrate scope, and is operationally simple.
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isatins, PCC, one-pot, intramolecular cyclization