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Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones

Feng Li*, Lei Lu and Pengcheng Liu

*School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China, Email:

F. Li, L. Lu, P. Liu, Org. Lett., 2016, 18, 2580-2583.

DOI: 10.1021/acs.orglett.6b00925 (free Supporting Information)

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An acceptorless coupling of o-aminobenzamides with methanol has been accomplished in the presence of the metal-ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(H2O)] to provide quinazolinones in good yields.

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Key Words

Quinazolinones, Microwave Synthesis

ID: J54-Y2016