tert-Butyl Nitrite: Organic Redox Cocatalyst for Aerobic Aldehyde-Selective Wacker-Tsuji Oxidation
Xiao-Shan Ning, Mei-Mei Wang, Chuan-Zhi Yao, Xian-Min Chen and Yan-Biao Kang*
*Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China, Email: ybkangustc.edu.cn
X.-S. Ning, M.-M. Wang, C.-Z. Yao, X.-M. Chen, Y.-B. Kang, Org. Lett., 2016, 18, 2700-2703.
DOI: 10.1021/acs.orglett.6b01165 (free Supporting Information)
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The use of tert-butyl nitrite as a simple organic redox cocatalyst instead of copper or silver salts enabled an aldehyde-selective aerobic Wacker-Tsuji oxidation. Various aldehydes could beg isolated as major products in up to 30/1 regioselectivity as well as good to high yields at room temperature.
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