Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters
Xingkuan Chen, Jacqueline Zi Mei Fong, Jianfeng Xu, Chengli Mou, Yunpeng Lu, Song Yang, Bao-An Song and Yonggui Robin Chi*
*Division of Chemistry & Biological Chemistry, School of
Physical & Mathematical Sciences, Nanyang Technological University, Singapore
637371, Singapore, Email: robinchi
ntu.edu.sg
X. Chen, J. Z. M. Fong, J. Xu, C. Mou, Y. Lu, S. Yang, B.-A. Song, Y. R. Chi, J. Am. Chem. Soc., 2016, 138, 7212-7215.
DOI: 10.1021/jacs.6b00406
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Abstract
A carbene-catalyzed reaction enables a dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield.
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Key Words
transesterification, organocatalysis
ID: J48-Y2016
