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Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters

Xingkuan Chen, Jacqueline Zi Mei Fong, Jianfeng Xu, Chengli Mou, Yunpeng Lu, Song Yang, Bao-An Song and Yonggui Robin Chi*

*Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore, Email: robinchintu.edu.sg

X. Chen, J. Z. M. Fong, J. Xu, C. Mou, Y. Lu, S. Yang, B.-A. Song, Y. R. Chi, J. Am. Chem. Soc., 2016, 138, 7212-7215.

DOI: 10.1021/jacs.6b00406 (free Supporting Information)


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Abstract

A carbene-catalyzed reaction enables a dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield.

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Key Words

transesterification, organocatalysis


ID: J48-Y2016