Amidines for Versatile Cobalt(III)-Catalyzed Synthesis of Isoquinolines through C-H Functionalization with Diazo Compounds
Jie Li*, Mengyao Tang, Lei Zang, Xiaolei Zhang, Zhao Zhang and Lutz Ackermann*
*Jiangnan University, Lihu Road 1800, 214122 Wuxi, P. R. China; Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany, Email: jjacklijiangnan.edu.cn, Lutz.Ackermannchemie.uni-goettingen.de
J. Li, M. Tang, L. Zang, X. Zhang, Z. Zhang, L. Ackermann, Org. Lett., 2016, 18, 2742-2745.
DOI: 10.1021/acs.orglett.6b01199 (free Supporting Information)
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A cobalt(III)-catalyzed C-H/N-H bond functionalization for the synthesis of 1-aminoisoquinolines from aryl amidines and diazo compounds proceeds under mild reaction conditions, obviates the need for oxidants, produces only N2 and H2O as the byproducts, and features a broad substrate scope.
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