Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides
Vittorio Pace*, Karen de la Vega-Hernández, Ernst Urban and Thierry Langer
*Department of Pharmaceutical Chemistry, University of
Vienna, Althanstrasse, 14, A-1090 Vienna, Austria, Email: vittorio.pace
univie.ac.at
V. Pace, K. de la Vega-Hernández, E. Urban, T. Langer, Org. Lett., 2016, 18, 2750-2753.
DOI: 10.1021/acs.orglett.6b01226
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Abstract
Addition of in situ generated Schwartz reagent to widely available isocyanates enables a chemoselective, high-yielding, and versatile synthesis of variously functionalized formamides. The reaction tolerates the presence of sensitive functionalities (esters, nitro groups, nitriles, alkenes).
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Key Words
ID: J54-Y2016
